pyusb is the usual way to talk to USB from Python, and it can drive a virtual device from either library - by loading the libusb-1.0 wrapper as its backend instead of the system libusb.

pyusb loads that backend from a path you choose, so pointing it at the wrapper needs no LD_PRELOAD and no copying a DLL. With the variables set in os.environ rather than the shell, this is the same code on every OS - only the file name changes:

import os
import usb.core, usb.backend.libusb1
 
# the wrapper reads these in libusb_init(), i.e. inside get_backend()
os.environ["USBIP_HOST"] = "127.0.0.1"
os.environ["USBIP_PORT"] = "3240"
 
# the usbip wrapper, not the system libusb:
#   Linux   /path/to/libusb-1.0.so.0
#   macOS   /path/to/libusb-1.0.0.dylib
#   Windows C:\path\to\libusb-1.0.dll
backend = usb.backend.libusb1.get_backend(find_library=lambda _: "/path/to/libusb-1.0.dll")
dev = usb.core.find(idVendor=0x1209, idProduct=0x0004, backend=backend)

The Python guide's pyusb page walks a full program through this, with the behavioural differences that matter to a pyusb caller (string indices read 0, no hotplug, timeouts not enforced - Wrappers).